• Fun Facts

    Post
    Australians are exposed to 2 millisieverts of 'background' radiation per year
    Post
    A CT of the chest can be roughly equivalent to having 100 single chest X-rays
    Post
    15x Melbourne → Singapore → London flights exposes you to 1 millisievert
  • Diagnostic X-rays

    A diagnostic X-ray is the oldest and most common medical radiology procedure. Radiologists use X-rays to help diagnose disease or injury inside your body. A machine directs a small, carefully calculated amount of radiation toward a specific part of the body to produce an image on a film on the other side of the body. Radiologists study the X-ray images to detect and diagnose disease or injury.

  • CT dosage

    Computed Tomography (CT) is currently one of the major contributors to the collective population radiation dose due to the increasing popularity of CT examinations as a non-invasive diagnostic tool. The evolution of CT scanner technology has turned their use from specialized into routine examination. More due diligence is required due to the high radiation dose of CT.

  • Where to from here?

    It is of the utmost importance that both clinical justification as well as technical optimization are implemented to maintain a high benefit to risk ratio. Solid interdisciplinary partnerships and research endeavours between clinical specialists and technology engineers will help to fast track developments in this area.

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2012 news

NHMRC Development Grant success

Congratulations to Andreas and colleagues for being awarded an NHMRC 2013 Development Grant for their project, "From the synchrotron to the clinic: translation of a novel functional lung imaging technology". The team were awarded $859,797 over 3 years to commercialise their technology. This sum also represents the largest Development Grant awarded to a team in the history of the grant.

Summer Research Program commences for 2012

As semester 2 exams draw to a close at Monash University, LDI welcomes our Summer Research Program undergraduate students who will be doing various placements within our laboratory over the next 3 months. We welcome Max, Kun, Garam, Felix, Jonathan and Sarah, of whom will be working on a variety of different projects from ventilator processor-board design, to implementation of chest wall measurement using lasers. We hope that all students have a very pleasant and intellectually fulfilling Summer with LDI.

Nature Medicine article featured in Nature Milestones

Elham, Dr Josie Carberry, Andreas and colleagues' 2009 Nature Medicine article, "A shear gradient–dependent platelet aggregation mechanism drives thrombus formation", has been featured in the Light Microscopy edition of Nature Milestones. The article describes how high-resolution intravital imaging techniques and hydrodynamic analyses are used to show that platelet aggregation is primarily driven by changes in blood flow parameters, not soluble agonists as previously assumed. Currently to date, the article has been cited over 100 times. Congratulations to all the authors.

For more information about the article, please visit our 2009 Publications page.

new horizons

Funding awarded for new LDI imaging facility

Andreas and LDI have been awarded funding from Monash University and the Faculty of Engineering to accelerate development into a new X-ray imaging facility to be used for interdisciplinary research with our present and future research collaborators. The $2M facility will be built and based in the New Horizons building, which is due for completion and scheduled to open in early 2013. The facility will bring together synchrotron technology and liaison with the Australian Synchrotron, MASSIVE supercomputing power and the Monash eResearch Centre, as well as collaboration with Monash Biomedical Imaging, and Monash University's Animal Research Platform. The ambitious and highly novel technology at the core of the facility is targeted at making a major impact — in both cutting edge research, but also with regards to positive societal impacts, most notably in Health and Medicine.

Dual-energy subtraction manuscript published in J Sync Rad

Congratulations to Richard, Andreas and Dr Marcus Kitchen (School of Physics) for their manuscript, Single-exposure dual-energy-subtraction X-ray imaging using a synchrotron source, published in Journal of Synchrotron Radiation today. For more information, please visit our 2012 Publications page.

Ex vivo XV manuscript published in J Sync Rad

Congratulations to Aidan, Dr Karen Siu (MBI, Australian Synchrotron), Steve, Dr James Armitage (Dept of Anatomy & Developmental Biology) and Andreas for their manuscript, X-ray velocimetry within the ex vivo carotid artery, published in Journal of Synchrotron Radiation today. For more information, please visit our 2012 Publications page.

Rabbit HFV manuscript published in PLoS One

Congratulations to Jordan, Steve, Aidan, Richard, Andreas and colleagues for their manuscript, Functional Lung Imaging during HFV in Preterm Rabbits, published in PLoS One today. For more information, please visit our 2012 Publications page.

SPring-8 synchrotron trip #2 for 2012

Andreas, Jordan and Richard, as well as colleagues from MiMR, School of Physics, along with collaborators from the Australian Synchrotron, Women's and Children's Hospital in Adelaide and Telethon Institute for Child Health Research in Perth, head back to the Japanese synchrotron SPring-8 to conduct an intense second round of experiments for the year focusing on lung disease, and lasting three weeks.

NHMRC Project Grant success

Congratulations to Dr Bang Bui (Optometry & Vision Sciences, University of Melbourne), Dr James Armitage (Dept of Anatomy & Developmental Biology, Monash University), Andreas and Prof Algis Vingrys (Optometry & Vision Sciences, University of Melbourne), on their NHMRC Project Grant funding success for their 3-year project, Age-related impairment of autoregulation: a modifiable risk factor for glaucoma.

Phase contrast optimisation manuscript published in J Appl Phys

Congratulations to Ivan, Dr David Paganin (School of Physics) and Andreas for their manuscript, Optimization of in-line phase contrast particle image velocimetry using a laboratory x-ray source, published in Journal of Applied Physics today. For more information, please visit our 2012 Publications page.

PEV manuscript published in Meas Sci Tech

Congratulations to Rajeev, Dr Josie Carberry, Dr Greg Sheard (Dept Mech & Aero) and Andreas for their manuscript, Polynomial element velocimetry (PEV): a technique for continuous in-plane velocity and velocity gradient measurements for low Reynolds number flows, published in Measurement Science and Technology today. For more information, please visit our 2012 Publications page.

Andreas and Jordan head for the USA

Andreas and Jordan head on a whirlwind tour of the U.S.A. Special interest will be attendance to the SPIE Symposium on Optics and Photonics — Developments in X-ray Tomography VIII in San Diego where Andreas is an invited speaker giving a talk on In vivo tomographic velocimetry of the lung for the detailed study of lung disease and its treatments. Jordan, also presenting at the same conference is giving his talk on Mapping cardiogenic oscillations using synchrotron based phase contrast CT imaging. Andreas will also be presenting a talk on behalf of first author, Rajeev, entitled, "Application of a novel diffraction-based tomography method for imaging biological samples".

Masters awarded to Jayne Nguyen

We are very pleased to announce that LDI student Jayne Nguyen has been awarded her Engineering Masters. Jayne's thesis titled "Ventilation system design for use in assisting premature infant respiration studies" was accepted in fulfillment of the requirements of the degree of Master of Engineering Science (Research) by the Monash University Faculty of Engineering Research Office. Congratulations!

Particle size manuscript published in Optics Express

Congratulations to Richard, Dr Marcus Kitchen (School of Physics) and Andreas for their manuscript, Determining particle size distributions from a single projection image, published in Optics Express today. For more information, please visit our 2012 Publications page.

SPring-8 synchrotron trip #1 for 2012

Andreas, Steve, Jordan, Richard, as well as colleagues from MiMR, School of Physics, along with collaborators from the Australian Synchrotron, Women's and Children's Hospital in Adelaide and Telethon Institute for Child Health Research in Perth, head to the Japanese synchrotron SPring-8 to conduct experiments in lung disease including asthma and cystic fibrosis.

PhD awarded to Elham Tolouei

We are very pleased to announce that LDI student Elham Tolouei has been awarded her PhD. Elham's thesis titled "Investigation of shear dependent platelet aggregation" was accepted in fulfillment of the requirements of the degree of Doctor of Philosophy by the Monash Research Graduate School. Congratulations!

American Asthma Foundation presentation

Andreas and research grant colleague Prof Stuart Hooper (MiMR) have flown to the U.S. to present their latest asthma research findings to the American Asthma Foundation, the granting body of their AAF asthma grant, and to liase and share thoughts with other AAF asthma grant recipients.

Breakfast with Red Symons radio interview on 774

Andreas featured in 774 ABC Melbourne's Breakfast with Red Symons morning radio program to casually discuss and enlighten the wider community on our group's research progress in using synchrotron radiation to make 4-dimensional analysis of lung motion. To hear the podcast, please visit 774 ABC Melbourne's Breakfast with Red Symons (May 7th 2012) podcast page.

Altered lung motion manuscript receives ABME cover

Congratulations to Andreas, Steve, and their multidisciplinary team of coauthors for their manuscript, Altered lung motion is a sensitive indicator of regional lung disease, published in Annals of Biomedical Engineering.

The research team are also proud to announce that they have received the cover image for the May 2012 edition of the journal.

The image depicts a colour map of regional divergence determined using X-ray velocimetry for a typical (left) control lung versus a typical (right) bleomycin-treated lung (6 days after exposure), showing abnormal regional motion. This quality of regional data has never been seen before and is not acquired with conventional pulmonary function tests. Matching histology is also shown.

For more information, please visit our 2012 Publications page.

JRSI research in ABC Science

Steve, Andreas, and collaborators Prof Stuart Hooper (MIMR) and Dr Karen Siu's (Monash Physics/Australian Synchrotron) recent Journal of Royal Society Interface publication, "Synchrotron-based dynamic computed tomography of tissue motion for regional lung function measurement" detailing our research on functional lung imaging, has featured in ABC-Science's report X-rays shed new light on lung function.

The technology we have developed allows measurement of lung function in unprecedented detail. We now have a goal of translating this technology for use in pharmaceutical development and towards clinical use in hospitals, "The team is now working to implement this technology into a human clinical scanner. This would result in a smaller and safer amount of radiation exposure than is emitted by current technologies such as CT scans".

For more information about the manuscript, please visit our 2012 Publications page.

Velocimetry manuscripts published in Exp in Fluids

Congratulations to Chuong Nguyen, Dr Josie Carberry and Andreas for their volumetric correlation manuscript, Volumetric-correlation PIV to measure particle concentration and velocity of micro flows, published in Experiments in Fluids. For more information, please visit our 2012 Publications page.

Congratulations to Rajeev, Andreas and coauthors for their temporal averaging manuscript, Optimisation of temporal averaging processes in PIV, published in Experiments in Fluids. For more information, please visit our 2012 Publications page.

Congratulations to Steve, Aidan, Simon, Andreas and coauthors for their computed tomographic X-ray velocimetry manuscript, Computed Tomographic X-ray Velocimetry for simultaneous 3D measurement of velocity and geometry in opaque vessels, published in Experiments in Fluids. For more information, please visit our 2012 Publications page.

Semester One begins

Semester One has commenced for the year. We are glad to announce that our postdoctoral fellow, Steve will be lecturing fourth year elective, ENG4700 Biomedical Imaging & Sensing, this year.

Summer research draws to a close

The Summer Research Program has once again concluded in anticipation of the beginning of Monash University's Semester 1 commencing on Monday. We wish our Summer Research students Warren, Gillian and Ming, the very best with the rest of his studies in Engineering and Biomedical Sciences, and also congratulate Pauline Assemat's student Gillian for her winning poster, presented to the Faculty of Engineering today.

Synchrotron mouse manuscript published in Gene Therapy

Congratulations to Aidan and coauthors for their synchrotron mouse airway manuscript, Synchrotron phase-contrast X-ray imaging reveals fluid dosing dynamics for gene transfer into mouse airways, published in Gene Therapy. For more information, please visit our 2012 Publications page.

Intracardiac PIV manuscript accepted for publication

Congratulations to Aidan, Andreas and Rob Bryson–Richardson for their intracardial PIV manuscript, Cardiac-Phase Filtering in Intracardiac Particle Image Velocimetry, accepted for publication in Journal of Biomedical Optics. For more information, please visit our 2012 Publications page.

LDI welcomes 2012

Monash University reopens after the Christmas Close Down, with LDI welcoming the new year and striving for even more research success this year.