LDI Alumni Profile
Dept. Mechanical & Aerospace Engineering, Monash University Clayton Campus
Supervisors: Professor Andreas Fouras, Associate Professor Greg Sheard & Professor Kerry Hourigan
Qualifications:BEng(Mechatronics, Hons) University of Canterbury NZ 2008, PhD Monash 2016
PhD topic:Realtime manipulation of cells using fluid flow
Biological cells exert a number of interesting mechanical properties and are able to both react to external mechanical stimulus and modify their mechanical properties in response to external (biochemical) stimulus, a phenomenon known as mechanotransduction. Some examples of cells which exhibit mechanotransduction include platelet cells (the cells in the blood responsible for clotting); the cells attached to the fine hair-like cilia in the inner-ear and heart muscle cells (cardiomyocytes). In addition, various disorders cause modification of cell mechanical properties, including the malaria parasite (which attacks haemoglobin); and all forms of cancers. Using fluid flow around the cell to exert controllable and variable forces, this project will investigate the mechanotransduction behaviour of individual cells in isolation to assist in gaining an understanding of the mechanical behaviours of diseased cells.
Feedback control system simulator for the control of biological cells in microfluidic cross slots and integrated microfluidic systems. Lab on a Chip, 11(14), 2343–2351.
- Tutor: TRC3500 Sensors and Artificial Perception, Monash University Clayton (2009–2012)